20-hydroxyeicosatetraenoic acid

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20-hydroxyeicosatetraenoic acid (20-HETE) is a natriuretic eicosanoid. It is derived from omega hydroxylation of arachidonic acid by the cytochrome P450 enzymes CYP4A and CYP4F. It is mitogenic under many circumstances[1][2], and inhibition of 20-HETE has been shown to inhibit several types of cell growth including angiogenesis.[3] Synthesis of 20-HETE can be inhibited by HET0016.


  1. Lin F, Rios A, Falck JR, Belosludtsev Y, and Schwartzman ML (1995) 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule. Am J Physiol 269:F806–F816.
  2. Uddin MR, Muthalif MM, Karzoun NA, Benter IF, and Malik KU (1998) Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling. Hypertension 31:242–247.
  3. Alonso-Galicia M, Falck JR, Reddy KM, and Roman RJ (1999) 20-HETE agonists and antagonists in the renal circulation. Am J Physiol 277:F790–F796.
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