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N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine, abbreviated HET0016, is a formamidine compound. It is a chemical inhibitor of the enzyme CYP4A, and thus 20-HETE synthesis. By inhibiting synthesis of 20-HETE, it acts as an angiogenesis inhibitor. HET0016 and derivatives of it have been suggested as potential drugs to fight glioma, a type of brain cancer, as it significantly reduces the growth of U251 cells in vitro[1].


  1. Guo M, Roman RJ, Falck JR, Edwards PA, and Scicli AG (2005) Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [N-Hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A. JPET 315:526–533.
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